selected publications

For complete publication lists see the corresponding sites of our team members.


A tough egg to crack: recreational boats as vectors for invasive goby eggs and transdisciplinary management approaches. 2016. Hirsch P.E.; Adrian-Kalchhauser I.; Flämig S.; N’Guyen A.; Defila R.; Di Giulio A.; Burkhardt-Holm P. Ecology and Evolution (doi:10.1002/ece3.1892)


Benzo(a)pyrene Metabolism and EROD and GST Biotransformation Activity in the Liver of Red- and White-Blooded Antarctic Fish. 2015. Strobel, A.; Burkhardt-Holm, P.; Schmid, P.; Segner, H. Environmental Science & Technology (doi:10.1021/acs.est.5b00176) abstract

What do we really know about the impacts of one of the 100 worst invaders in Europe? A reality check. 2015. Hirsch, P.E.; N’Guyen, A. *(shared first authorship); Adrian-Kalchhauser I.; Burkhardt-Holm P.  Ambio (doi:10.1007/s13280-015-0718-9)

Improving invasive species management by integrating priorities and contributions of scientists and decision makers. 2015. N’Guyen A.;  Hirsch P.E.; *(shared first authorship); Adrian-Kalchhauser I.; Burkhardt-Holm P. Ambio (doi:10.1007/s13280-015-0723-z)

Movement patterns and shelter choice of spiny-cheek crayfish (Orconectes limosus) in a large lake’s littoral zone. 2015, Hirsch P.E.; Burkhardt-Holm P.; Töpfer I.; Fischer P. Aquatic Invasions 11 (in press).

Individual identification of Eurasian perch Perca fluviatilis by means of their stripe patterns. 2015. Hirsch P.E.; Eckmann R.; Limnologica 54: 1-4. 


In vivo effects of deoxynivalenol (DON) on innate immune responses of carp (Cyprinus carpio L.). 2014. Pietsch, C., Michel, C., Kersten, S., Valenta, H., Dänicke, S., Schulz, C., Kloas, W., Burkhardt-Holm, P. Food and Chemical Toxicology 68: 44-52 download

Natural mineral particles are cytotoxic to rainbow trout gill epithelial cells in vitro. 2014. Michel, C., Herzog, S., de Capitani, C., Burkhardt-Holm, P. & Pietsch, C. PLoS ONE, 9 (7): 1-11 download

Acute exposure to a common suspended sediment affects the swimming performance and physiology of juvenile salmonids. 2014. Berli, B.I., Gilbert, M.J.H., Ralph, A.L., Tierney, K. B. & Burkhardt-Holm, P. Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology, 176: 1-10

Transient exposure to environmental estrogen affects embryonic development of brown trout (Salmo trutta fario). 2014. Schubert, S., Peter, A., Schönenberger, R., Suter, M. J.-F., Segner, H., Burkhardt-Holm, P. Aquatic Toxicology 157: 141-149

A hydro-economic model for water level fluctuations: combining limnology with economics for sustainable development of hydropower. 2014. Hirsch, P.E., Schillinger, S., Weigt, H., Burkhardt-Holm, P. PLoS ONE 9(12): 1-26 download

The complete mitochondrial genome of the invasive Ponto-Caspian goby Ponticola kessleri obtained from high-throughput sequencing using the lon Torrent Personal Genome Machine. 2014. Kalchhauser, I., Kutschera, V.E., Burkhardt-Holm, P. GDNA Mitochondrial DNA, Early Online: 1-3


Indirect trophic interactions with an invasive species affect phenotypic divergence in a top consumer. 2013. Hirsch PE, Eklöv P Svanbäck R ,DOI 10.1007/s00442-013-2611-1, Oecologia, 172(1)245-256 download

Suspended sediment pulse effects in rainbow trout Oncorhynchus mykiss – relating apical and systemic responses. 2013. Michel C, Schmidt-Posthaus H, Burkhardt-Holm P . DOI 10.1139/cjfas-2012-0376, Canadian Journal of Fisheries and Aquatic Sciences70(4):630-641 download

Arrival of round goby Neogobius melanostomus (Pallas, 1814) and bighead goby Ponticola kessleri (Günther, 1891) in the High Rhine (Switzerland). 2013. Kalchhauser I, Mutzner P, Hirsch P, Burkhardt-Holm P.  BioInvasion Records (2)1:79-83 download

Molecular crosstalks between a chemical and a biological stressor and consequences on disease manifestation in a rainbow trout. 2013. Burki, R., Krasnov, A., Bettge, K., Rexroad III, C.E., Afanasyev, S., Antikainen, M., Burkhardt-Holm, P., Wahli, T., Segner, H. Aquatic Toxicology, 127:2-8

Life-cycle exposure to the estrogenic mycotoxin zearalenone affects zebrafish (Danio rerio) development and reproduction. 2013. Schwartz, P., Bucheli Th.D., Wettstein, F.E. & Burkhardt-Holm, P. Environmental Toxicology28 (5): 276-289 download

ATTN: publications without the possibility to download can be requested from the authors


Measurement of spatial and temporal fine sediment dynamics in a small river. Schindler Wildhaber Y, Michel C, Burkhardt-Holm P, Bänninger D, Alewell C. 2012. Hydrology and Earth System Sciences 16:1501-1515 download

Uptake and effects of microplastics on cells and tissue of the blue mussel Mytilus edulis L. after an experimental exposure. Von Moos N, Burkhardt-Holm P, Köhler A. 2012. Environmental Science and Technology. download

Variability in swimming performance and underlying physiology in rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta). Ralph AL, Berli BI, Burkhardt-Holm P, Tierny KB. 2012. Comparative Biochemistry and Physiology, Part A 163:350-356 download

Pathogenic infection confounds induction of the estrogenic biomarker Vitellogenin in rainbow trout.
Burki R, Krasnov A, Bettge K, Rexroad CE, Afanasyev S, Antikainen M, Burkhardt-Holm P, Wahli T, Segner H. Environmental Toxicology and Chemistry, 31(10):2318-2323 download


Molecular and cellular effects of chemicals disrupting steroidogenesis during early ovarian development of brown trout (Salmo trutta fario). A Marca Pereira ML, Eppler E, Thorpe KL, Wheeler JR, Burkhardt-Holm P. 2011. Environmental Toxicology. download

Mode of sexual differentiation and its influence on the relative sensitivity of the fathead minnow and zebrafish in the fish sexual development test. Thorpe KL, Pereira ML, Schiffer H, Burkhardt-Holm P, Weber K, Wheeler JR. 2011. Aquat Toxicol. 105(3-4):412-20. download

Frequent biphasic cellular responses of permanent fish cell cultures to deoxynivalenol (DON). Pietsch C, Bucheli TD, Wettstein FE, Burkhardt-Holm P. 2011. Toxicology and Applied Pharmacology 256(1):24-34. download

Life-cycle exposure to the estrogenic mycotoxin zearalenone affects zebrafish (Danio rerio) development and reproduction. Schwartz P, Bucheli TD, Wettstein FE, Burkhardt-Holm P. 2011. Environmental Toxicology 1522-7278. download

Embryotoxic and genotoxic potential of sewage system biofilm and river sediment in the catchment area of a sewage treatment plant in Switzerland. Häfeli N, Schwartz P, Burkhardt-Holm P. 2011. Ecotoxicol Environ Saf. 74(5):1271-9. download

Development of an ex vivo brown trout (Salmo trutta fario) gonad culture for assessing chemical effects on steroidogenesis. A Marca ML, Wheeler JR, Thorpe KL, Burkhardt-Holm P. 2011. Aquatic Toxicology 101:500-511. download

How hormonally active substances in our environment affect humans and wildlife - What do we know and what can be done? Burkhardt-Holm P. 2011. On the Water Front 2:50-63. download

Linking water quality to human health and environment: the fate of micropollutants. Burkhardt-Holm P. 2011. Institute of Water Policy Working Paper series 3. download


Short-term exposure to the environmentally relevant estrogenic mycotoxin zearalenone impairs reproduction in fish. Schwartz P, Thorpe KL, Bucheli TD, Wettstein FE, Burkhardt-Holm P. 2010. Science of the Total Environment 409:326-333. download

Pathogenic infection attenuates the response of the estrogenic biomarker, vitellogenin, in rainbow trout. Burki R, Wahli T, Segner H, Burkhardt-Holm P, Rexroad CE, Afanasyev S, Antikainen M, Krasnov A. 2010. Comparative Biochemistry and Physiology a-Molecular, Integrative Physiology, 157(1):23. download

Polychlorierte Biphenyle (PCB) in Gewässern der Schweiz. Daten zur Belastung von Fischen und Gewässern mit PCB und Dioxinen, Situationsbeurteilung. Schmid P, Markus Z, Holm P, Pietsch C, Brüschweiler B, Kuchen A, Staub E, Tremp J. 2010. Umwelt-Wissen Nr. 1002, Bundesamt für Umwelt, Bern. 101 S. download

Educating Experts for Sustainable Development: The Master's Degree in Sustainable Development at the University of Basel. Burger P, Burkhardt-Holm P, Krysiak FC. 2010. In: Darbellay, F., Paulsen, Th. (eds.), Im Spiegel der Disziplinen - Gedanken über inter- und transdisziplinäre Forschungs- und Lehrpraktiken. Verlag Peter Lang, 133-153.

Endocrine Disruptors and Water Quality: A State-of-the-Art Review. Burkhardt-Holm P. 2010. International Journal of Water Resources Development, 26: 3, 477- 493. download

Faszinierende Fische – Biologie, Bedeutung und Zukunft. Holm P. 2010. Haupt-Verlag, Bern.

Kinder und Karriere - ein Spagat, der zu meistern ist. Holm, P. 2010. In: Piechulla, B. (ed.), Professorin und Mutter - wie geht das?, Spektrum Akademischer Verlag, Heidelberg, 48-55.


Fischpopulationen unter Stress – das Beispiel des Unteren Neckars. Braunbeck T, Hollert H, Brauns A, Keiter S, Schwartz P. 2009. Umweltwiss. Schadst. Forsch. 21:197-211. download

Diversity and evolution of MHII β genes in a non-model percid species, the Eurasian perch (Perca fluviatilis L.). Michel C, Bernatchez L, Behrmann-Godel J. 2009. Molecular Immunology 46(2009):3399-3410. download

Klimawandel und Bachforellenrückgang - gibt es einen Zusammenhang? Resultate in der Schweiz. Burkhardt-Holm P. 2009. Umweltwiss. Schadst. Forsch. 21:177-185. download

Climate and land-use changes affecting river sediment and brown trout in alpine countries - a review.
Scheurer K, Alewell Ch, Bänninger D, Burkhardt-Holm P. 2009. Environ. Sci. Pollut. Res. 16:232-242. download

Estrogenic wastewater treatment works effluents reduce egg production in fish. Thorpe KL, Maack G, Benstead R, Tyler CR. 2009. Environmental Science and Technology 43(8):2976-2982. download

Progesterons cause immunosuppression of stimulated carp (Cyprinus carpio L.) leukocytes in vitro. Pietsch D, Neumann N, Knopf K, Wuertz S, Kloas W. 2009. Comparative Biochemistry and Physiology C 150(1):16-24. download

Psychologie des Umdenkens und Umlernens - wie Umweltpsychologie zur nachhaltigen Entwicklung beitragen kann. Interviewleitung: Hajmer, A. Burkhardt-Holm P. 2009. In: Mitteilungen des Verbandes für Geoökologie in Deutschland e.V. (VGöD), Forum der Geoökologie 20 (2).


Water temperature and concomitant waterborne ethinylestradiol exposure affects the vitellogenin expression in juvenile brown trout (Salmo trutta). Körner O, Kohno S, Schönenberger R, Suter MJF, Knauer K, Guillette LJ, Burkhardt-Holm P. 2008. Aquatic Toxicology 90:188-196. download

Sensitivity of brown trout reproduction to long-term estrogenic exposure. Schubert S, Peter A, Burki R, Schönenberger R, Suter MJF, Segner H, Burkhardt-Holm P. 2008. Aquatic Toxicology 90:65-72. download

Decline of brown trout (Salmo trutta) in Switzerland - How to assess potential causes in a multi-factorial cause-effect relationship. Burkhardt-Holm P. 2008. Mar. Environ. Res. 66/1:181-182. download

Master's Degree in Sustainable Development in Switzerland, the first master course comprising three faculties. Burkhardt-Holm P, Chebbi C. 2008. Env Sci Pollut Res 15(2):136-142. download

Estrogenic endocrine disruption in Switzerland – assessment of fish exposure and effects. Burkhardt-Holm P, Segner H, Burki R, Peter A, Schubert S, Suter MJF, Borsuk ME. 2009. Chimia 62:376-382. download

Fischnetz: Involving anglers, authorities, scientists and the chemical industry to understand declining fish yields. Burkhardt-Holm P. 2008. In: G. Hirsch Hadorn, H. Hoffmann-Riem, S. Biber-Klemm, W. Grossenbacher, D. Joye, C. Pohl, U. Wiesmann and E. Zemp (eds), Handbook of Transdisciplinary Research, Springer, 127-142. download


Occurrence of polybrominated diphenyl ethers (PBDEs) in brown trout bile and liver from Swiss rivers. Hartmann PC, Burkhardt-Holm P, Giger W. 2007. Environm. Poll. 146:107-113. download

Lebenswissenschaften und Allgemeine Ökologie. Gemeinsamkeiten, Unterschiede und gegenseitige Beeinflussung.
Burkhardt-Holm P, Segner H. 2007. In: Di Giulio, A., Defila, R., Hammer, T., Bruppacher, S. (eds), Allgemeine Ökologie. Innovationen in Wissenschaft und Gesellschaft. Festschrift für Ruth Kaufmann-Hayoz, Haupt Verlag, Bern, 103-125. download

Project Fischnetz: Decline of fish catch in Switzerland. Burkhardt-Holm P. 2007. Aquat. Sci. 69(1):1-2. download

Application of the weight-of-evidence approach to assess the decline of brown trout (Salmo trutta) in Swiss rivers. Burkhardt-Holm P, Scheurer K. 2007. Aquat. Sci. 69(1):51-70. download

Reproductive health of brown trout inhabiting Swiss rivers with declining fish catch. Körner O, Vermeirssen ELM, Burkhardt-Holm P. 2007. Aquatic Sciences 69(1):26-40. download

Status of young-of-the-year brown trout (Salmo trutta fario) in Swiss streams: factors influencing YOY trout recruitment. Schager E, Peter A, Burkhardt-Holm P. 2007. Aquat. Sci. 69(1):41-50. download

Assessment of fish health status in four Swiss rivers showing a decline of brown trout catches. Zimmerli S, Bernet D, Burkhardt-Holm P, Schmidt-Posthaus H, Vonlanthen P, Wahli T, Segner H. 2007. Aquat. Sci. 69(1):11-25. download


Estrogenicity patterns in the Swiss midland river Lützelmurg in relation to treated domestic sewage effluent discharges and hydrology. Vermeirssen ELM, Suter MJF, Burkhardt-Holm P. 2006. Environmental Toxicology and Chemistry 25(9):2413-2422. download

Assessment of estrogenic exposure in brown trout (Salmo trutta) in a Swiss midland river – integrated analysis of passive samplers, wild and caged fish, and vitellogenin mRNA and protein. Burki R, Vermeirssen ELM, Körner O, Joris C, Burkhardt-Holm P, Segner H. 2006. Environmental Toxicology and Chemistry 25(8):2077-2086. download

Assessing the decline of brown trout (Salmo trutta) in Swiss rivers using a Bayesian probability network. Borsuk ME, Reichert P, Peter A, Schager E, Burkhardt-Holm P. 2006. Ecological Modelling 192:224-244. download

Was ist mit unseren Fischen los? Holm O. 2006. In: Fisch und Fischer aus zwei Jahrtausenden. Eine fischereiwirtschaftliche Zeitreise durch die Nordwestschweiz. Forschungen in Augst, Schwabe, Co. AG, Muttenz. download

Consequences of climatic change for water temperature and brown trout populations in Alpine rivers and streams. Hari RE, Livingstone DM, Siber R, Burkhardt-Holm P, Güttinger H. 2006. Global Change Biology 12:10-26. download


Characterization of environmental estrogens in river water using a three pronged approach: active and passive water sampling and the analysis of accumulated estrogens in the bile of caged fish. Vermeirssen ELM, Körner O, Schönenberger R, Suter MJF, Burkhardt-Holm P. 2005. Environmental Science and Technology 39:8191-8198. download

Where have all the fish gone? Burkhardt-Holm P, Giger W, Güttinger H, Ochsenbein U, Peter A, Scheurer K, Segner H, Staub E. 2005. Environmental Science and Technology 39:441A-447A. download

Characterization of the estrogenicity of Swiss midland rivers using a recombinant yeast bioassay and plasma vitellogenin concentrations in feral male brown trout. Vermeirssen ELM, Burki R, Joris C, Peter A, Segner H, Suter MJF, Burkhardt-Holm P. 2005. Environmental Toxicology and Chemistry 24(9):2226-2233. download

Intersex in feral brown trout from Swiss midland rivers. Körner O, Vermeirssen ELM, Burkhardt-Holm P. 2005. Journal of Fish Biology 67:1734-1740. download


Dem Fischrückgang auf der Spur. Fischnetz. Kurzbericht des Projekts Netzwerk Fischrückgang. Schipper O, Suter M, Holm P. 2004. Bundesamt für Umwelt, Schweiz. download

Dem Fischrückgang auf der Spur. Fischnetz. Schlussbericht. Meili M, Scheurer K, Schipper O, Holm P. 2004. Bundesamt für Umwelt, Schweiz. download


Full texts of the publications are available from the authors on request.